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The component in human transfer factor (TF) (Fraction IV, from exclusion chromatography on Sephadex G-25) responsible for suppression of antigen-induced lymphocyte transformation was previously identified as nicotinamide. Commercially available nicotinamide was subsequently shown to produce suppression of antigen-induced responses in vitro previously observed with TF Fraction IV. Nicotinamide was found to be nontoxic at the highest concentrations employed (10(-2)M) and suppressive over a relatively broad range (10(-5) to 10(-2)M. The suppression appeared to be related to the magnitude of antigen- or mitogen-induced transformation and was apparent even when nicotinamide was added as late as 48 hr after stimulant addition.
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
January 1984,
Allergologia et immunopathologia,
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
January 1969,
Acta haematologica,
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
October 1971,
The Journal of laboratory and clinical medicine,
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
January 1983,
TSitologiia i genetika,
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
September 1973,
Lancet (London, England),
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
September 1973,
Lancet (London, England),
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
January 1979,
Materia medica Polona. Polish journal of medicine and pharmacy,
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
February 1982,
Arerugi = [Allergy],
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
January 1978,
Lancet (London, England),
D R Burger, and
A A Vandenbark, and
D Daves, and
W A Anderson, and
R M Vetto, and
P Finke
April 1970,
Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research,
