Bronchial asthma due to sensitization to chloramine T. 1992

A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
Allergy Service, Clínica Puerta de Hierro, Madrid, Spain.

Chloramine T, an organic, highly reactive derivative of chlorine with potent bactericidal properties, is used as a disinfectant in the food industry. Described as an occupational sensitizer in 1945 for the first time, it produces late or dual asthma, occasionally accompanied by fever and leukocytosis, which is mediated by IgE. We present the case of a male dairy worker who, after 4 years of exposure to the product, developed rhinitis and asthma. Skin tests with chloramine T were positive at a concentration of 10 mg/ml, while all other allergens tested negative. RAST detected specific IgE at 12 PRU and bronchial provocation induced immediate and late bronchoconstriction.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D011852 Radioallergosorbent Test An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies. Radioimmunosorbent Assay of Allergens,Allergens Radioimmunosorbent Assay,Allergens Radioimmunosorbent Assays,Radioallergosorbent Tests,Test, Radioallergosorbent,Tests, Radioallergosorbent
D002700 Chloramines Inorganic derivatives of ammonia by substitution of one or more hydrogen atoms with chlorine atoms or organic compounds with the general formulas R2NCl and RNCl2 (where R is an organic group). Chloroamines
D004202 Disinfectants Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) Biocide,Disinfectant,Biocides
D004342 Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally. Allergy, Drug,Hypersensitivity, Drug,Drug Allergy,Allergies, Drug,Drug Allergies,Drug Hypersensitivities,Hypersensitivities, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas

Related Publications

A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
November 1995, Respiratory medicine,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
September 1952, Revista clinica espanola,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
January 1995, Duodecim; laaketieteellinen aikakauskirja,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
July 1979, British medical journal,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
August 1979, British medical journal,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
January 2003, Journal of investigational allergology & clinical immunology,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
July 1961, Giornale di clinica medica,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
January 1981, International archives of allergy and applied immunology,
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
August 2005, Occupational medicine (Oxford, England),
A Blasco, and A Joral, and R Fuente, and M Rodríguez, and A García, and A Domínguez
September 1974, Zeitschrift fur Hautkrankheiten,
Copied contents to your clipboard!