BIOMAT Database Logo BIOMAT Database Logo

On the mechanism of action of reserpine: effect of reserpine on capacity of tissues to bind serotonin. 1957

B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE

UI MeSH Term Description Entries
D012110 Reserpine An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine

Related Publications

B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
[Effect of the inhibition of monoaminoxidase on serotonin action; relation to the mechanism of reserpine action].
January 1957, Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
Serotonin release as a possible mechanism of reserpine action.
August 1955, Science (New York, N.Y.),
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
[On the effect of serotonin and reserpine on in vitro oxygen consumption by rat tissues].
January 1961, Acta physiologica Polonica,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
The role of brain serotonin in the mechanism of the central action of reserpine.
May 1966, The Journal of pharmacology and experimental therapeutics,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
Persistence of reserpine action after the disappearance of drug from brain: effect on serotonin.
September 1956, The Journal of pharmacology and experimental therapeutics,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
Researches on the mechanism of reserpine sedative action.
November 1958, Science (New York, N.Y.),
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
Effect of reserpine analogues on tissue serotonin.
March 1960, Experientia,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
[Mechanism of action of reserpine].
March 1959, Klinische Wochenschrift,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
[Research on the mechanism of reserpine action on the hypophysis].
January 1961, Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
B B BRODIE, and E G TOMICH, and R KUNTZMAN, and P A SHORE
[On the effects of serotonin and reserpine on the oxygen consumption of rat tissues].
September 1960, Wiener klinische Wochenschrift,
Copied contents to your clipboard!