A specific course of the reparative process in the skin under the influence of low-energy laser radiation was studied in albino rats by a complex of methods. High phagocytic activity of macrophages was observed as early as 6 h after trauma. It resulted in rapid debridement of the wound and prepared conditions for the proliferation phase. At later terms (5 and 10 days) the reaction to laser irradiation manifested itself as a powerful vascularization of the wound and increased amount of secreting fibroblasts. Favorable conditions for the reparative process resulting from the laser action were responsible for its optimum result as well. Cicatrization of the wound in animals given laser therapy was accompanied by the formation of hair follicles and the structure of the scar approximated to the structure of the intact skin.