BIOMAT Database Logo BIOMAT Database Logo

Effects of a new calcium antagonist, manidipine, on the renal hemodynamics and the vasoactive humoral factors in patients with diabetes mellitus. 1992

H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University Fukuoka, Kanagawa, Japan.

The effects of manidipine (10 mg/day for 7 days) on the renal hemodynamics and vasoactive humoral factors were examined in 6 adults with diabetes mellitus (DM). Mean duration of DM was 9 +/- 2 years; serum creatinine concentration was 0.9 +/- 0.04 mg/dL. Plasma endothelin-1 (ET-1) concentration was 5.4 +/- 0.7 pg/mL before manidipine, compared with 1.9 +/- 0.2 pg/mL in 14 controls (p = 0.03%). Systolic and mean blood pressure decreased significantly during treatment without changes in glomerular filtration rate, renal plasma flow, or filtration fraction. Renal vascular resistance tended to decrease and fractional excretion of sodium significantly increased from 1.35 +/- 0.27% to 2.06 +/- 0.47 (p = 2.96%). ET-1 significantly decreased from 5.4 +/- 0.7 pg/mL to 3.5 +/- 0.6 (p = 2.95%), while plasma angiotensin II, atrial natriuretic factor, urinary excretion rate of ET-1, and albumin excretion rate did not change. Manidipine lowers blood pressure without adversely affecting renal function in diabetic patients. Manidipine, which lowers ET-1, may protect from progressive renal injury in diabetics.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009320 Atrial Natriuretic Factor A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. ANF,ANP,Atrial Natriuretic Peptide,Atrial Natriuretic Peptides,Atriopeptins,Auriculin,Natriuretic Peptides, Atrial,ANF (1-126),ANF (1-28),ANF (99-126),ANF Precursors,ANP (1-126),ANP (1-28),ANP Prohormone (99-126),ANP-(99-126),Atrial Natriuretic Factor (1-126),Atrial Natriuretic Factor (1-28),Atrial Natriuretic Factor (99-126),Atrial Natriuretic Factor Precursors,Atrial Natriuretic Factor Prohormone,Atrial Natriuretic Peptide (1-126),Atrial Pronatriodilatin,Atriopeptigen,Atriopeptin (1-28),Atriopeptin (99-126),Atriopeptin 126,Atriopeptin Prohormone (1-126),Cardiodilatin (99-126),Cardiodilatin Precursor,Cardionatrin I,Cardionatrin IV,Prepro-ANP,Prepro-CDD-ANF,Prepro-Cardiodilatin-Atrial Natriuretic Factor,Pro-ANF,ProANF,Proatrial Natriuretic Factor,Pronatriodilatin,alpha ANP,alpha-ANP Dimer,alpha-Atrial Natriuretic Peptide,beta-ANP,beta-Atrial Natriuretic Peptide,gamma ANP (99-126),gamma-Atrial Natriuretic Peptide,Natriuretic Peptide, Atrial,Peptide, Atrial Natriuretic,Peptides, Atrial Natriuretic,Prepro ANP,Prepro CDD ANF,Prepro Cardiodilatin Atrial Natriuretic Factor,Pro ANF,alpha ANP Dimer,alpha Atrial Natriuretic Peptide,beta ANP,beta Atrial Natriuretic Peptide,gamma Atrial Natriuretic Peptide
D009578 Nitrobenzenes BENZENE derivatives carrying nitro group substituents.
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D012079 Renal Circulation The circulation of the BLOOD through the vessels of the KIDNEY. Kidney Circulation,Renal Blood Flow,Circulation, Kidney,Circulation, Renal,Blood Flow, Renal,Flow, Renal Blood
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002121 Calcium Channel Blockers A class of drugs that act by selective inhibition of calcium influx through cellular membranes. Calcium Antagonists, Exogenous,Calcium Blockaders, Exogenous,Calcium Channel Antagonist,Calcium Channel Blocker,Calcium Channel Blocking Drug,Calcium Inhibitors, Exogenous,Channel Blockers, Calcium,Exogenous Calcium Blockader,Exogenous Calcium Inhibitor,Calcium Channel Antagonists,Calcium Channel Blocking Drugs,Exogenous Calcium Antagonists,Exogenous Calcium Blockaders,Exogenous Calcium Inhibitors,Antagonist, Calcium Channel,Antagonists, Calcium Channel,Antagonists, Exogenous Calcium,Blockader, Exogenous Calcium,Blocker, Calcium Channel,Blockers, Calcium Channel,Calcium Blockader, Exogenous,Calcium Inhibitor, Exogenous,Channel Antagonist, Calcium,Channel Blocker, Calcium,Inhibitor, Exogenous Calcium

Related Publications

H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Renal effects of manidipine hydrochloride. A new calcium antagonist in hypertensive patients.
January 1993, European journal of clinical pharmacology,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Effects of the calcium antagonist manidipine on renal hemodynamics and function in dogs: comparison with nifedipine.
January 1992, Blood pressure. Supplement,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Effect of manidipine, a new calcium antagonist, on intrarenal hemodynamics in essential hypertension.
January 1992, Blood pressure. Supplement,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Pharmacologic characteristics of a new calcium antagonist, manidipine: beneficial effects on renal circulation and vascular changes.
February 1993, American heart journal,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Effect of calcium antagonist, manidipine hydrochloride, on renal hemodynamics and tubuloglomerular feedback in spontaneously hypertensive rats.
February 1993, American heart journal,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Renal long-term effects of calcium antagonist treatment in patients with diabetes mellitus.
October 1992, The Clinical investigator,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
[Effects of a new vasoactive substance on renal hemodynamics].
July 1973, Minerva medica,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
[Renal hemodynamics in patients with diabetes mellitus].
November 1981, Vrachebnoe delo,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Effects of a calcium antagonist, manidipine, on progressive renal injury associated with mild hypertension in remnant kidneys.
May 1995, The Journal of laboratory and clinical medicine,
H Hirakata, and K Iino, and I Ishida, and M Kashiwagi, and M Yoshinari, and S Okuda, and S Fujita, and M Fujishima
Isradipine, a new calcium antagonist: effects on maternal and fetal hemodynamics.
January 1991, Journal of cardiovascular pharmacology,
Copied contents to your clipboard!