Biomaterial Database

Effect of herbicides on human skin. Penetration of herbicides through the epidermis "in vitro". 1992

V Kaspárková, and P Hybásek

Department of Dermatology and Venerology, Medical Faculty, Palacky University, Olomouc, Czechoslovakia.

Penetration of herbicides GRAMOXONE and REGLONE through human epidermis was studied "in vitro". A special diffusion equipment was used and the method of Calderbank and Yuen was modified for quantitative determination of efficient components (paraquat, diquat) of both herbicides. Penetration of the chosen herbicides was different and surfactants contained in herbicides were found to play a role in penetration into the skin.

UI	MeSH Term	Description	Entries
D010269	Paraquat	A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.	Methyl Viologen,Gramoxone,Paragreen A,Viologen, Methyl
D004058	Diffusion	The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.	Diffusions
D004178	Diquat	A contact herbicide used also to produce desiccation and defoliation. (From Merck Index, 11th ed)	Diquat Dibromide,Dibromide, Diquat
D006540	Herbicides	Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.	Algaecide,Algicide,Herbicide,Algaecides,Algicides
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In