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The axillary lymph nodes from two patients with invasive breast carcinoma showed "signet ring" histiocytosis with sinusoidal distribution of cells having prominent cytoplasmic vacuolization which simulated metastatic adenocarcinoma. Immunohistochemical studies confirmed the histiocytic nature of the signet ring cells and eliminated the possibility of metastatic adenocarcinoma. Electron microscopy in one case revealed lipid within the cytoplasmic vacuoles. The etiology of this reactive change is unknown; however, a history of previous surgery involving the chest wall may be causally related with disruption of adipose tissue. Prior to ipsilateral mastectomy both patients had undergone a contralateral mastectomy for mammary carcinoma. Signet ring sinus histiocytosis is a reactive sinusoidal proliferation that can mimic metastatic carcinoma, but close inspection will usually reveal the histiocytic nature of the cells.
A R Frost, and
Y H Shek, and
E E Lack
July 1997,
Cancer,
A R Frost, and
Y H Shek, and
E E Lack
October 1989,
American journal of clinical pathology,
A R Frost, and
Y H Shek, and
E E Lack
December 2010,
Ultrastructural pathology,
A R Frost, and
Y H Shek, and
E E Lack
December 1990,
American journal of clinical pathology,
A R Frost, and
Y H Shek, and
E E Lack
April 1985,
The American journal of surgical pathology,
A R Frost, and
Y H Shek, and
E E Lack
January 1992,
Oral surgery, oral medicine, and oral pathology,
A R Frost, and
Y H Shek, and
E E Lack
April 1986,
Medicina clinica,
A R Frost, and
Y H Shek, and
E E Lack
June 2003,
Annals of diagnostic pathology,
A R Frost, and
Y H Shek, and
E E Lack
January 1993,
Acta cytologica,
A R Frost, and
Y H Shek, and
E E Lack
February 1998,
Pathology international,
