BIOMAT Database Logo BIOMAT Database Logo

Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. 1992

B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Department of Medicine (GI Division), University of Maryland, Baltimore.

Allelic deletions of tumor suppressor genes have been observed frequently in a variety of human tumors. These losses are believed to contribute to the development of human cancer. Three of the most frequently deleted chromosomal loci contain the tumor suppressor genes p53, retinoblastoma (Rb), and mcc/apc. In order to detect loss of heterozygosity (LOH) within these genes in dysplastic and cancerous ulcerative colitis, we used an application of the polymerase chain reaction. LOH affecting p53 was observed in 8 of 17 (47%) of heterozygous patients, while LOH of Rb and the mcc/apc locus was observed in 9 of 27 (33%) and 13 of 39 (33%) of heterozygotes, respectively. Among 35 patients heterozygous at 2 or more loci, LOH of p53, Rb, and/or mcc/apc was observed in 18 (51%). LOH was more common in left-sided neoplasms. These data suggest that allelic deletion of p53, Rb, mcc, and/or apc is involved in the pathogenesis and/or progression of at least a subset of colonic dysplasias and carcinomas occurring in the setting of ulcerative colitis.

UI MeSH Term Description Entries
D007438 Introns Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes. Intervening Sequences,Sequences, Intervening,Intervening Sequence,Intron,Sequence, Intervening
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009838 Oligodeoxyribonucleotides A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties. Oligodeoxynucleotide,Oligodeoxyribonucleotide,Oligodeoxynucleotides
D011230 Precancerous Conditions Pathological conditions that tend eventually to become malignant. Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D003110 Colonic Neoplasms Tumors or cancer of the COLON. Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005091 Exons The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. Mini-Exon,Exon,Mini Exon,Mini-Exons
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes

Related Publications

B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Loss of heterozygosity at the p53, RB, DCC and APC tumor suppressor gene loci in human bladder cancer.
April 1996, The Journal of urology,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.
June 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Aberrations of tumor-suppressor genes (p53, apc, mcc and Rb) in esophageal squamous-cell carcinoma.
April 1994, International journal of cancer,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Bilateral adrenocortical carcinoma showing loss of heterozygosity at the p53 and RB gene loci.
June 1996, Cancer genetics and cytogenetics,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Study of loss of heterozygosity at DCC and APC/MCC genetic loci of gastric cancer.
June 1999, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
[The possible role of loss of heterozygosity at APC, MCC and DCC genetic loci in esophageal carcinoma].
January 1999, Zhonghua zhong liu za zhi [Chinese journal of oncology],
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.
April 1994, The Journal of urology,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Semiautomated quantitative detection of loss of heterozygosity in the tumor suppressor gene p53.
June 1995, BioTechniques,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
April 1992, Proceedings of the National Academy of Sciences of the United States of America,
B D Greenwald, and N Harpaz, and J Yin, and Y Huang, and Y Tong, and V L Brown, and T McDaniel, and C Newkirk, and J H Resau, and S J Meltzer
[A study on the loss of heterozygosity at the APC/MCC and DCC genetic loci in colorectal cancers].
July 1996, Zhonghua nei ke za zhi,
Copied contents to your clipboard!