BIOMAT Database Logo BIOMAT Database Logo

Antihypertensive and metabolic effects of concomitant administration of terazosin and methyclothiazide for the treatment of essential hypertension. 1992

H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Yale University School of Medicine.

The efficacy and safety of once-daily 2.5- or 5.0-mg methyclothiazide (MCTZ) added to once-daily 5.0-mg terazosin (TRZ) versus 5.0-mg TRZ alone was evaluated in this double-blind, multicenter study. All patients received TRZ during a 6-week titration period. Hypertensive patients (222) (mean blood pressure of 159/104 mm Hg) were randomized to one of three treatment groups: TRZ alone (N = 76); TRZ+MCTZ-2.5 mg (N = 74); and TRZ+MCTZ-5.0 mg (N = 72) for the 8-week double-blind period. Changes in the supine and standing SBP/DBP from preTRZ period were: TRZ alone (-4.8/-8.1 and -2.6/-6.1 mm Hg); TRZ+MCTZ-2.5 mg (-17.3/-12.4 and -16.0/-11.2 mm Hg); and TRZ+MCTZ-5.0 mg (-20.6/-14.4 and -23.3/-14.6 mm Hg). Blood pressure changes in the combination groups were significantly greater than those in the TRZ alone group. However, there were no statistically significant differences between the TRZ+MCTZ-2.5-mg and TRZ+MCTZ-5.0-mg groups. The combination of TRZ and MCTZ tends to mitigate the adverse effects on serum glucose, uric, potassium and lipids usually associated with thiazide diuretics. Thus, combination treatment that begins with TRZ and adds MCTZ is effective in lowering blood pressure without any significant adverse metabolic effects.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008736 Methyclothiazide A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011224 Prazosin A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION. Furazosin,Minipress,Pratsiol,Prazosin HCL,Prazosin Hydrochloride,HCL, Prazosin,Hydrochloride, Prazosin
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females

Related Publications

H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Concomitant administration of terazosin and atenolol for the treatment of essential hypertension.
March 1988, Archives of internal medicine,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
[Pressure and metabolic effects of terazosin in essential hypertension].
June 1994, Cardiologia (Rome, Italy),
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Metabolic effects of combined antihypertensive treatment in patients with essential hypertension.
December 2002, Journal of cardiovascular pharmacology,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
[Treatment of essential arterial hypertension by the methyclothiazide-deserpidine].
May 1967, Revista brasileira de medicina,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Comparison of antihypertensive and lipid actions of terazosin and atenolol in essential hypertension.
June 1992, Journal of human hypertension,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
The effects of terazosin and methyclothiazide on blood pressure and serum lipids.
April 1989, American heart journal,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Antihypertensive effects of doxazosin in systemic hypertension and comparison with terazosin.
May 1987, The American journal of cardiology,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Timing for administration of an antihypertensive drug in the treatment of essential hypertension.
January 1994, Hypertension (Dallas, Tex. : 1979),
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
A combination of methyclothiazide and deserpidine in the treatment of essential hypertension.
August 1962, Diseases of the chest,
H R Black, and S G Chrysant, and C L Curry, and W H Frishman, and R H Grimm, and K C Lasseter, and R Okun, and J L Pool, and V Raizada, and N D Vlachakis
Pargyline hydrochloride combined with methyclothiazide in the treatment of essential hypertension.
August 1966, Current therapeutic research, clinical and experimental,
Copied contents to your clipboard!