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The effect of p-chlorophenylalanine-treatment in rats receiving chronic treatment with tranylcypromine on brain serotonin and 5-hydroxyindoleacetic acid levels was examined. This treatment schedule was similar to that followed in depressed patients undergoing treatment with the monoamine oxidase inhibitor. PCPA completely obviated the elevation in serotonin and further reduced 5-HIAA levels of animals treated chronically with tranylcypromine. These effects correlated with PCPA-induced reversal in the clinical improvement achieved by tranylcypromine. In in vitro studies, tranylcypromine was found to inhibit 5-HT uptake into synaptosomes with a minimal action on the spontaneous release of the amine.
E Friedman, and
B Shopsin, and
S Gershon
November 1996,
Neuroscience letters,
E Friedman, and
B Shopsin, and
S Gershon
October 1982,
European journal of pharmacology,
E Friedman, and
B Shopsin, and
S Gershon
January 1991,
Annals of the New York Academy of Sciences,
E Friedman, and
B Shopsin, and
S Gershon
March 1977,
Acta pharmacologica et toxicologica,
E Friedman, and
B Shopsin, and
S Gershon
January 1994,
Journal of psychiatry & neuroscience : JPN,
E Friedman, and
B Shopsin, and
S Gershon
May 1985,
European journal of pharmacology,
E Friedman, and
B Shopsin, and
S Gershon
February 1962,
Archives internationales de pharmacodynamie et de therapie,
E Friedman, and
B Shopsin, and
S Gershon
June 2001,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
E Friedman, and
B Shopsin, and
S Gershon
December 1978,
Psychopharmacology,
E Friedman, and
B Shopsin, and
S Gershon
January 1970,
The American journal of psychiatry,
