Biomaterial Database

Is sodium necessary for stimulus-secretion coupling in toad (Caudiverbera caudiverbera) adrenal chromaffin cells? 1992

V Nassar-Gentina, and P Aguilar, and M Luxoro

Laboratorio de Fisiologia Celular, Facultad de Ciencias, Universidad de Chile, Vina del Mar.

1. Chromaffin cells of the toad were used to investigate the effects of total replacement of extracellular Na+ by monovalent cations or sucrose on secretion of catecholamine (CA). 2. K+, Rb+ or Cs+ in place of Na+ produced an immediate secretory response, which are dependent on extracellular Ca2+ and it was blocked by Co2+. Li+ or choline+ did not affect basal secretion. 3. Isosmotic replacement of Na+ by sucrose caused CA secretion even in the absence of external Ca2+ or in the presence of Ca-channel blockers. 4. Tetraethylammonium decreased the extent of CA release produced by either K+ or Rb+. 5. The secretagogue effect of Na+/K+, Na+/Rb+ or Na+/Cs+ replacement could be explained by a depolarization of the cell membrane, which ultimately will cause Ca2+ influx through voltage-dependent Ca-channels. However, the present results indicate that Na+ may be sufficient but not necessary for CA secretion.

UI	MeSH Term	Description	Entries
D008094	Lithium	An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	Lithium-7,Lithium 7
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D002586	Cesium	A member of the alkali metals. It has an atomic symbol Cs, atomic number 55, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.	Caesium,Caesium-133,Cesium-133,Caesium 133,Cesium 133
D002794	Choline	A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.	Bursine,Fagine,Vidine,2-Hydroxy-N,N,N-trimethylethanaminium,Choline Bitartrate,Choline Chloride,Choline Citrate,Choline Hydroxide,Choline O-Sulfate,Bitartrate, Choline,Chloride, Choline,Choline O Sulfate,Citrate, Choline,Hydroxide, Choline,O-Sulfate, Choline
D002838	Chromaffin System	The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.	Argentaffin System,Argentaffin Systems,Chromaffin Systems,System, Argentaffin,System, Chromaffin,Systems, Argentaffin,Systems, Chromaffin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001001	Anura	An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.	Bombina,Frogs and Toads,Salientia,Toad, Fire-Bellied,Toads and Frogs,Anuras,Fire-Bellied Toad,Fire-Bellied Toads,Salientias,Toad, Fire Bellied,Toads, Fire-Bellied
D012413	Rubidium	An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23