[Immunoglobulin E and its relation to bronchial asthma]. 1976

E Spanár, and J Cáp, and R Pullmann, and V Záhradný, and A Levcík, and J Holan

This paper presents a comparison of the levels of IgE in blood serum in a group of healthy persons, a group of persons suffering on asthma bronchiale of an infectious type and of the group of patients suffering in atopic type of asthma bronchiale. The quantitative estimation of IgE in sera was accomplished by the radioimmunoassay "Phadebas IgE Test". The blood levels of IgE of healthy persons and those suffering on infectious asthma bronchiale had no striking differences. The patients suffering on atopic asthma bronchiale showed a tremendous rise of blood IgE, that could be suppressed by the therapeutic application of corticosteroids (Triamcinolon). After the withdrawal of corticosteroids a new rise of blood IgE has been observed. During the application of corticosteroids there was an evident suppression of plasmatic cortisol levels, which rose after their therapeutic withdrawal.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D014221 Triamcinolone A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) Aristocort,Volon

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