[Leukocyte migration inhibition test in skin chamber--an in-vivo method]. 1976

V Wätzig, and K Ruffert, and G Güldner

For the demonstration of a cell-mediated sensitisation, tuberculin allergics, chromate allergics, penicillin allergics, and controls were investigated. The method used was the measurement of leukocyte migration inhibition in a Teflon skin chamber with and without addition of antigen, which approaches to testing under in vivo conditions. In 10 of 11 tuberculin allergics, 6 of 7 chromate allergics, and 7 penicillin allergics, a clear inhibition of leucocyte migration after addition of antigen could be observed (maximum 16 h after addition of antigen). In 16 unsensitised controls no significant migration inhibition appeared. Possible advantages of this method over in vitro methods and intracutaneous tests are discussed.

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D010406 Penicillins A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065) Antibiotics, Penicillin,Penicillin,Penicillin Antibiotics
D002464 Cell Migration Inhibition Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms. Chemotaxis Inhibition,Chemotaxis Inhibitions,Inhibition, Chemotaxis,Inhibitions, Chemotaxis
D002840 Chromates Salts of chromic acid containing the CrO(2-)4 radical. Chromate
D004342 Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally. Allergy, Drug,Hypersensitivity, Drug,Drug Allergy,Allergies, Drug,Drug Allergies,Drug Hypersensitivities,Hypersensitivities, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012882 Skin Tests Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity. Skin Test,Test, Skin,Tests, Skin
D012884 Skin Window Technique A technique to study CELL MIGRATION in the INFLAMMATION process or during immune reactions. After an area on the skin is abraded, the movement of cells in the area is followed via microscopic observation of the exudate through a coverslip or tissue culture chamber placed over the area. Rebuck Skin Window Technique,Skin Window Technic,Skin Window Technics,Skin Window Techniques,Technic, Skin Window,Technics, Skin Window,Technique, Skin Window,Techniques, Skin Window
D014373 Tuberculin A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons. PPD,PPD-B,PPD-CG,PPD-F,PPD-L,PPD-S,Purified Protein Derivative of Tuberculin,PPD B,PPD CG,PPD F,PPD L

Related Publications

V Wätzig, and K Ruffert, and G Güldner
March 1997, Nihon rinsho. Japanese journal of clinical medicine,
V Wätzig, and K Ruffert, and G Güldner
January 1991, Laboratornoe delo,
V Wätzig, and K Ruffert, and G Güldner
May 1980, Klinicheskaia meditsina,
V Wätzig, and K Ruffert, and G Güldner
January 1980, Laboratornoe delo,
V Wätzig, and K Ruffert, and G Güldner
July 2005, Nihon rinsho. Japanese journal of clinical medicine,
V Wätzig, and K Ruffert, and G Güldner
November 1999, Nihon rinsho. Japanese journal of clinical medicine,
V Wätzig, and K Ruffert, and G Güldner
October 1976, Polski tygodnik lekarski (Warsaw, Poland : 1960),
V Wätzig, and K Ruffert, and G Güldner
October 1977, International journal of dermatology,
V Wätzig, and K Ruffert, and G Güldner
April 1981, Rinsho byori. The Japanese journal of clinical pathology,
V Wätzig, and K Ruffert, and G Güldner
January 1983, Przeglad dermatologiczny,
Copied contents to your clipboard!