BIOMAT Database Logo BIOMAT Database Logo

Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. 1992

Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Division of Emergency Medicine and Critical Care Medicine, Kyoto University School of Medicine, Japan.

There is currently accumulating evidence for bidirectional communication between the neuroendocrine and immune systems. Various cytokines have been suggested to be involved in the stimulation of stress hormone secretion during the times of infection and inflammation. To assess the possible involvement and pathophysiologic significance of cytokines in the mechanisms responsible for the perioperative stress response of the hypothalamo-pituitary-adrenal axis, we observed the changes of plasma adrenocorticotropic hormone and cortisol levels together with those of plasma endotoxin and cytokine levels. In patients undergoing pancreatoduodenectomy, perioperative stimulation of adrenocorticotropic hormone and cortisol secretion was accompanied by a significant elevation of plasma cytokine levels. Application of epidural block up to the upper thoracic levels failed to suppress this stress response effectively. In patients undergoing unilateral total hip replacement, the response of plasma hormone levels was smaller and briefer with no significant increase of plasma cytokine levels. Application of epidural block up to the lower thoracic levels suppressed this hormonal response almost completely. In patients undergoing pancreatoduodenectomy, a significant elevation of plasma endotoxin level was followed by a gradual but significant elevation of plasma tumor necrosis factor alpha and interleukin-6 levels. It seems likely that the stimulatory effects of these cytokines on the secretion of adrenocorticotropic hormone and cortisol might be involved in the development of the greater and more prolonged stress response of hypothalamo-pituitary-adrenal axis. Our present study suggests that not only neural input from the surgical wound but also stimulation of cytokine production were responsible for the development of the stress response of the hypothalamo-pituitary-adrenal axis during and after upper abdominal surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007432 Intraoperative Period The period during a surgical operation. Intraoperative Periods,Period, Intraoperative,Periods, Intraoperative
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011184 Postoperative Period The period following a surgical operation. Period, Postoperative,Periods, Postoperative,Postoperative Periods
D004731 Endotoxins Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells. Endotoxin
D006622 Hip Prosthesis Replacement for a hip joint. Femoral Head Prosthesis,Femoral Head Prostheses,Hip Prostheses,Prostheses, Femoral Head,Prostheses, Hip,Prosthesis, Femoral Head,Prosthesis, Hip
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000324 Adrenocorticotropic Hormone An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000767 Anesthesia, Epidural Procedure in which an anesthetic is injected into the epidural space. Anesthesia, Extradural,Anesthesia, Peridural,Epidural Anesthesia,Anesthesias, Epidural,Anesthesias, Extradural,Anesthesias, Peridural,Epidural Anesthesias,Extradural Anesthesia,Extradural Anesthesias,Peridural Anesthesia,Peridural Anesthesias

Related Publications

Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Plasma cortisol responses during neurosurgical and abdominal operations.
December 1971, British journal of anaesthesia,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Evaluation of plasma cortisol and corticosterone responses to synthetic adrenocorticotropic hormone administration in ferrets.
January 1993, American journal of veterinary research,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Variability of cortisol and adrenocorticotropic hormone responses to metoclopramide during the menstrual cycle.
January 1989, Gynecologic and obstetric investigation,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Plasma cortisol and progesterone responses to low doses of adrenocorticotropic hormone in ovariectmized lactating cows.
December 2006, The Journal of reproduction and development,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Adrenocorticotropic hormone and cortisol in calves after corticotropin-releasing hormone.
August 1999, Journal of animal science,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Plasma renin activity, aldosterone, and cortisol responses to a short-acting intravenous adrenocorticotropic hormone test.
May 1986, Archives of internal medicine,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Thyroid hormones, catecholamine and cortisol concentrations after upper abdominal surgery.
January 1984, Acta chirurgica Scandinavica,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Plasma levels of beta-endorphin, adrenocorticotropic hormone and cortisol during early and late alcohol withdrawal.
January 2001, Alcohol and alcoholism (Oxford, Oxfordshire),
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Effects of androgen on plasma levels of adrenocorticotropic hormone and cortisol during transportation in goats.
November 2005, The Journal of veterinary medical science,
Y Naito, and S Tamai, and K Shingu, and K Shindo, and T Matsui, and H Segawa, and Y Nakai, and K Mori
Paradoxical responses of plasma cortisol, adrenocorticotropic hormone and growth hormone to thyrotropin-releasing hormone and luteinizing-hormone-releasing hormone in anorexia nervosa patients.
January 1986, Psychotherapy and psychosomatics,
Copied contents to your clipboard!