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It was tested whether T lymphocytes, when stimulated in vitro by M locus-coded lymphocyte activating determinants (LAD), are able to mediate cytotoxic effector functions. The assay for cytotoxicity included both the use of purified appropriate target cells (i.e. purified lipopolysaccharide blasts) as well as the use of phytohemagglutinin dependent cytolysis as a model for detecting cytotoxic T lymphocytes (CTL). Although strong proliferative responses were obtained in the mixed lymphocyte culture, the T cell blast generated did not display any detectable cytotoxic effector function. Thus, it is concluded that LAD, at least in the M locus-dependent system, do have the capacity to induce T cell proliferation but do not induce CTL.
M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
December 1977,
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M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
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M Röllinghoff, and
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H Trostmann, and
H Wagner
December 1978,
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M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
September 1973,
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M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
October 1982,
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M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
March 1980,
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M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
December 1978,
Journal of immunology (Baltimore, Md. : 1950),
M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
January 2019,
The Journal of dermatology,
M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
November 1980,
Cellular immunology,
M Röllinghoff, and
K Pfizenmeier, and
H Trostmann, and
H Wagner
March 1986,
Journal of immunology (Baltimore, Md. : 1950),
