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The purpose of this study was to examine the change in apolipoprotein and lipoprotein levels in patients with normolipidemic untreated non-insulin-dependent diabetes mellitus (NIDDM). Fifteen untreated, non-obese male NIDDM patients without hyperlipidemia were chosen, and 15 healthy subjects, matched for age, sex, body weight, alcohol consumption and cigarette smoking served as the control group. We observed that the concentrations of plasma total cholesterol (TC), triacylglycerol (TG) and very low density lipoprotein cholesterol (VLDL-C) were identical in both NIDDM and control groups. The levels of low-density lipoprotein cholesterol (LDL-C) were slightly increased in the diabetic group, but the difference did not reach statistical significance in our study. High-density lipoprotein cholesterol (HDL-C) was lower in the NIDDM group than in the controls. Significantly increased TC/HDL-C and LDL-C/HDL-C ratios were found in NIDDM patients compared with controls. The apolipoprotein A-I (apo A-I) and apolipoprotein A-II (apo A-II) levels were decreased in NIDDM patients, while the apolipoprotein B (apo B) level remained similar to that of the control subjects. The ratio of apo A-I/apo B was decreased significantly in the NIDDM group. Our results suggest that NIDDM patients are at higher risk of coronary heart disease, even if they remain normolipidemic.
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
January 1991,
Diabete & metabolisme,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
August 1994,
Lancet (London, England),
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
September 1988,
Medicina clinica,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
January 1997,
British medical bulletin,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
January 1994,
Current therapy in endocrinology and metabolism,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
July 1997,
Journal of the American Academy of Nurse Practitioners,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
January 1997,
Current therapy in endocrinology and metabolism,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
June 1988,
Primary care,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
January 1990,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
Y C Horng, and
J S Wei, and
R S Chang, and
H S Huang, and
M J Huang, and
B Y Huang
June 1994,
Atherosclerosis,
