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A possible role for somatostatin in affective disorders is suggested by its low concentration in cerebrospinal fluid of patients with depression. Therefore, we studied the regional effects of antidepressant drugs and antimanic agents on somatostatin concentrations in rat brain. Repeated, but not acute, administration of clomipramine, a specific serotonin uptake inhibitor, caused a highly significant, widespread reduction in somatostatin levels. Somatostatin content was similarly reduced in the hypothalamus, and midbrain and thalamus following repeated administration of zimelidine, another specific serotonin uptake inhibitor. Repeated administration of either imipramine, maprotiline, mianserin, carbamazepine or zotepine were without effect on somatostatin levels. These results suggest that somatostatin in the brain might be involved in therapeutic effects of some of antidepressant drugs.
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
December 1999,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
July 1995,
Journal of neurochemistry,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
January 1987,
Acta physiologica Polonica,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
January 1990,
Psychoneuroendocrinology,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
January 1997,
Journal of neural transmission (Vienna, Austria : 1996),
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
June 1975,
Endocrinology,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
May 1977,
Brain research,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
March 1983,
British journal of pharmacology,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
July 1995,
Progress in neuro-psychopharmacology & biological psychiatry,
T Kakigi, and
K Maeda, and
H Kaneda, and
K Chihara
February 1992,
European journal of pharmacology,
