A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia. 1992

M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
Division of Anaesthesia, Royal Infirmary, Glasgow.

Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6 mg.kg-1 or vecuronium 0.1 mg.kg-1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train-of-four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003473 Neuromuscular Nondepolarizing Agents Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. Curare-Like Agents,Curariform Drugs,Muscle Relaxants, Non-Depolarizing,Neuromuscular Blocking Agents, Competitive,Nondepolarizing Blockers,Agents, Curare-Like,Agents, Neuromuscular Nondepolarizing,Blockers, Nondepolarizing,Curare Like Agents,Drugs, Curariform,Muscle Relaxants, Non Depolarizing,Non-Depolarizing Muscle Relaxants,Nondepolarizing Agents, Neuromuscular
D005260 Female Females
D006221 Halothane A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) 1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
August 1993, Canadian journal of anaesthesia = Journal canadien d'anesthesie,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
August 1989, Acta anaesthesiologica Scandinavica,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
June 1983, British journal of anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
January 1998, Anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
June 1983, British journal of anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
January 1996, Paediatric anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
February 1996, Anaesthesia and intensive care,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
January 1996, British journal of anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
February 1993, Anaesthesia,
M G Booth, and B Marsh, and F M Bryden, and E N Robertson, and W L Baird
September 1994, Journal of anesthesia,
Copied contents to your clipboard!