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Human brain cDNA clones for the myelin associated enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) have been isolated and sequenced. The only 5' untranslated region (UTR) sequence found was that of a human CNPII mRNA, with no direct evidence for a CNPI mRNA. Human CNPase cDNAs were used to isolate genomic clones containing the human CNPase gene which is 9 kb long. Four exons were identified, separated by three introns, and the sequence of each exon and intron/exon boundary has been established. The polymerase chain reaction (PCR) was used to detect the presence of the human CNPase gene in DNA from a panel of rodent/human somatic cell hybrids. By this means the human CNPase gene was mapped to chromosome 17. In situ hybridization of a human CNPase genomic clone to metaphase chromosomes further localized this gene to chromosomal band 17q21.
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
July 1993,
Gene,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
December 1989,
Biochemical and biophysical research communications,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
December 1981,
Biochimica et biophysica acta,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
November 1982,
Brain research,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
June 1988,
Journal of neurochemistry,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
January 1985,
Brain research,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
February 2005,
Journal of molecular biology,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
September 2005,
The Journal of urology,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
January 2005,
International journal of impotence research,
A J Douglas, and
M F Fox, and
C M Abbott, and
L J Hinks, and
G Sharpe, and
S Povey, and
R J Thompson
May 1981,
Brain research,
