-transparent.png){kind=logo}
Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor. 1992
University of Melbourne, Department of Medicine, Austin/Repatriation Hospital, Heidelberg, Victoria, Australia.
Anomalously low affinities for the beta-1-adrenoceptor are seen for members of a series of para-substituted N-isopropylphenoxypropanolamines in which the substituent is able to conjugate with the aromatic ring. The energy of conjugation was calculated using the AM1 semiempirical molecular orbital method and appears to correlate with the loss of binding energy, and hence affinity for the receptor. This suggests that binding is associated with movement of the substituent out of the plane of the aromatic ring due to steric interference with the receptor. A previously unrecognized binding site for aromatic groups off the para position is also identified.
Related Publications
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
June 1979,
Biochemical pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
May 1980,
Archives internationales de pharmacodynamie et de therapie,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
August 1976,
British journal of clinical pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
November 1988,
European journal of pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
August 1993,
European journal of pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
February 1987,
Archives internationales de pharmacodynamie et de therapie,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
August 1978,
Life sciences,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
October 1982,
Biochemical pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
January 1983,
Journal of cardiovascular pharmacology,
J B Ball, and
T L Nero, and
D Iakovidis, and
L Tung, and
G Jackman, and
W J Louis
November 1970,
Postgraduate medical journal,
