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The probability of hippocampal long-term potentiation induction in the mossy fiber CA3 and commissural/associational CA3 responses and the cortical levels of choline acetyltransferase (ChAT) activity were compared in right nucleus basalis magnocellularis (NBM)-lesioned rats. A 50% reduction in the right cortical ChAT activity was demonstrated 4 weeks after an ibotenic acid lesion of the NBM. No significative differences were found in the probability of LTP induction of right hippocampal slices in sham-operated rats from 10 to 40 days after the injection into the right NBM. On the contrary, a progressive and significative increase in the probability of LTP induction was shown in right hippocampal slices of NBM-lesioned rats from 10 to 40 days after the injection of ibotenic acid into the right NBM. The results demonstrated the appearance of a paradoxical increase of hippocampal synaptic plasticity when the cortical cholinergic biochemical alterations are still present. This finding might be responsible for a behavioural recovery, in NBM-lesioned rats.
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
January 1999,
The International journal of neuroscience,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
January 2000,
The International journal of neuroscience,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
September 1994,
Brain research,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
October 1997,
The International journal of neuroscience,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
January 2002,
The International journal of neuroscience,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
May 1994,
Neuroscience letters,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
September 1997,
The International journal of neuroscience,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
July 2017,
Arquivos de neuro-psiquiatria,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
August 2004,
Pharmacology, biochemistry, and behavior,
C Frank, and
S Sagratella, and
T Niglio, and
M G Caporali, and
E Bronzetti, and
A Scotti de Carolis
August 1994,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
