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A very potent non-protein toxin was isolated from the sea anemone Radianthus macrodactylus with the use of chromatography on polytetrafluoroethylene, CM-Sephadex C-25 and by cation and anion exchange HPLC. The toxin was identified as palytoxin by u.v.-, i.r.- and 500 MHz 1H NMR spectroscopy. Its LD50 was 0.74 +/- 0.29 micrograms/kg by i.v. injection into mice. So far, palytoxin has been associated with zoanthids only. The toxin caused the loss of haemoglobin from erythrocytes but only in about 2 hr after the beginning of incubation, which is characteristic for palytoxin from zoanthids. Sea anemone palytoxin was divided into major and minor components by HPLC. The latter proved to be a product of degradation of palytoxin.
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
August 2002,
Toxicon : official journal of the International Society on Toxinology,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
May 1990,
Bioorganicheskaia khimiia,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
July 1988,
Bioorganicheskaia khimiia,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
January 2006,
Biomeditsinskaia khimiia,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
March 2007,
Biochemistry. Biokhimiia,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
January 1988,
Doklady Akademii nauk SSSR,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
September 2004,
Toxicon : official journal of the International Society on Toxinology,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
January 1984,
Doklady Akademii nauk SSSR,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
April 2010,
Toxicon : official journal of the International Society on Toxinology,
V M Mahnir, and
E P Kozlovskaya, and
A I Kalinovsky
April 2006,
Toxicon : official journal of the International Society on Toxinology,
