BIOMAT Database Logo BIOMAT Database Logo

Preliminary clinical trial of p-di-2-chloroethyl-amino-L-phenylalanine (CB 3025, melphalan) and of di-2-chloroethyl methanesulfonate (CB 1506). 1958

R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW

UI MeSH Term Description Entries
D008466 Mechlorethamine A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. Chlorethazine,Chlormethine,Mechlorethamine Oxide,Mustine,Nitrogen Mustard,Nitrogen Mustard N-Oxide,Bis(2-chloroethyl)methylamine,Caryolysine,Cloramin,Embichin,Mechlorethamine Hydrochloride,Mechlorethamine Hydrochloride N-Oxide,Mechlorethamine N-Oxide,Methylchlorethamine,Mitomen,Mustargen,NSC-10107,NSC-762,Nitrogranulogen,Nitromin,Hydrochloride N-Oxide, Mechlorethamine,Hydrochloride, Mechlorethamine,Mechlorethamine Hydrochloride N Oxide,Mechlorethamine N Oxide,N-Oxide, Mechlorethamine Hydrochloride,N-Oxide, Nitrogen Mustard,NSC 10107,NSC 762,NSC10107,NSC762,Nitrogen Mustard N Oxide
D008558 Melphalan An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen. Medphalan,Merphalan,Phenylalanine Mustard,Sarcolysine,Sarkolysin,4-(Bis(2-chloroethyl)amino)phenylalanine,Alkeran,L-PAM,Mustard, Phenylalanine
D008698 Mesylates Organic salts or esters of methanesulfonic acid. Mesilate,Methanesulfonates,Mesilates,Mesylate,Methylenesulfonates
D009588 Nitrogen Mustard Compounds A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens. Compounds, Nitrogen Mustard,Mustard Compounds, Nitrogen
D010649 Phenylalanine An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. Endorphenyl,L-Phenylalanine,Phenylalanine, L-Isomer,L-Isomer Phenylalanine,Phenylalanine, L Isomer
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy

Related Publications

R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
CLINICAL TRIAL OF P-DI(2-CHLOROETHYL)AMINO-L-PHENYLALANINE (MELPHALAN) IN MULTIPLE MYELOMA.
January 1964, Giornale italiano di chemioterapia,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
[di-(2-chloroethyl)amino]-L-phenylalanine ("Melphalan")].
April 1962, Revista espanola de reumatismo y enfermedades osteoarticulares,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
Action of p-[di(2-chloroethyl)]-amino-l-phenylalanine on Harding-Passey mouse melanoma.
June 1956, Science (New York, N.Y.),
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
Further studies on the toxicity of 2-chloroethyl methanesulfonate (NSC-18016, CB-1506) for the dog.
June 1961, Cancer chemotherapy reports,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
Cyto-active amino-acids and peptides. XV. The synthesis of p-di-(2-chloroethyl) aminophenyl-L-alanine (melphalan) labelled with tritium.
January 1968, Journal of the Chemical Society. Perkin transactions 1,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
P-(Di-2-chloroethyl) aminophenylbutyric acid (CB 1348) in the treatment of cancer.
April 1958, Annals of the New York Academy of Sciences,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
[p-(N, N-Di-2-chloroethyl)-aminophenylbutyric acid (CB-1348) in oncological therapy].
September 1960, La Clinica terapeutica,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
Observations on the therapeutic activity and toxicity of 2-chlorethyl methanesulfonate-CB-1506 (NSC-18016).
November 1960, Cancer chemotherapy reports,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
[Effect of a peptide complex of m-di-(2-chloroethyl)amino-L-phenylalanine on some immunological reactions].
January 1971, Bollettino dell'Istituto sieroterapico milanese,
R PAPAC, and D A GALTON, and M TILL, and E WILTSHAW
[Cytotoxic activity of alkyl sulfonates. VII. Probable mechanism of action of 2-chloroethyl-methanesulfonate (C. B. 1506) & of 2-fluoroethyl methanesulfonate].
March 1959, Bollettino della Societa italiana di biologia sperimentale,
Copied contents to your clipboard!