Efficacy of stellate ganglion block: a clinical study with bupivacaine. 1992

E L Malmqvist, and M Bengtsson, and J Sörensen
Department of Anaesthesiology, University Hospital, Linköping, Sweden.

OBJECTIVE When administering stellate ganglion blocks (e.g., to pain patients), it may be essential to know whether the sympathetic block is complete. The aim of the present study was to study the efficacy of stellate ganglion blocks using different concentrations and volumes of local anesthetic and different sites of injection. METHODS Fifty-four stellate ganglion blocks (cervicothoracic sympathetic blocks) were performed for relief of chronic pain in 30 patients, all with a pre-block palmar skin temperature 32 degrees C or lower. Bupivacaine in random combinations of concentration (high, 5 mg/ml; low, 2.5 mg/ml), volume (high, 15-20 ml; low, 5-10 ml), and site of injection (C6 or C7) was used. The efficacy of these combinations was assessed by registering the following changes in effector organ activity: (1) observed signs (e.g., Horner's syndrome: miosis, ptosis, enophthalmos, and reddening of the sclera) and (2) objective measurements of changes in skin temperature, skin blood flow (laser Doppler flowmetry), skin resistance response, and in skin resistance level. RESULTS Only 15 of 54 blocks met four of the five criteria for an effective block: a Horner's syndrome in combination with an increased skin temperature (to > or = 34 degrees C), increased skin blood flow ( > or = 50%), and completely abolished skin resistance response on both the radial and the ulnar sides of the blocked hand. Only six of those 54 met all five criteria: they also had an increase ( > or = 13%) in skin resistance level on the radial and ulnar sides. Injection toward C7 instead of injection toward C6, and high concentration instead of low, seemed to be more advantageous, whereas volume seemed to be of less importance. A relationship between pre-block skin temperature and the rise in temperature during the block was found. CONCLUSIONS It was difficult to achieve a block that met all five established criteria. When assessing the efficacy of a stellate ganglion block, it is essential to evaluate the effects on vasoconstrictor and sudomotor fibers.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D002045 Bupivacaine A widely used local anesthetic agent. 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide,Bupivacain Janapharm,Bupivacain-RPR,Bupivacaina Braun,Bupivacaine Anhydrous,Bupivacaine Carbonate,Bupivacaine Hydrochloride,Bupivacaine Monohydrochloride, Monohydrate,Buvacaina,Carbostesin,Dolanaest,Marcain,Marcaine,Sensorcaine,Svedocain Sin Vasoconstr,Bupivacain RPR
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005712 Galvanic Skin Response A change in electrical resistance of the skin, occurring in emotion and in certain other conditions. Electric Conductance, Skin,Electrodermal Response,Reflex, Psychogalvanic,Skin Electric Conductance,Conductance, Skin Electric,Conductances, Skin Electric,Electric Conductances, Skin,Electrodermal Responses,Galvanic Skin Responses,Psychogalvanic Reflex,Response, Electrodermal,Response, Galvanic Skin,Responses, Electrodermal,Responses, Galvanic Skin,Skin Response, Galvanic,Skin Responses, Galvanic
D005730 Ganglionic Blockers Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery. Ganglionic Blocking Agents,Ganglioplegic Agents,Blocking Agents, Ganglionic,Ganglionic Blockaders,Agents, Ganglionic Blocking,Agents, Ganglioplegic,Blockaders, Ganglionic,Blockers, Ganglionic
D006732 Horner Syndrome A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating)(see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11) Bernard Syndrome,Horner's Syndrome,Miosis, Innervational Defect,Oculosympathetic Syndrome,Bernard's Syndrome,Claude Bernard-Horner Syndrome,Horner Syndrome, Acquired,Horner Syndrome, Central,Horner's Syndrome, Pupil,Ophthalmoplegia, Sympathetic Ocular,Ptosis Sympathetic,Sympathetic Ocular-Ophthalmoplegia,Acquired Horner Syndrome,Bernard Syndromes,Bernards Syndrome,Central Horner Syndrome,Claude Bernard Horner Syndrome,Horner Syndrome, Pupil,Horners Syndrome,Horners Syndrome, Pupil,Ocular Ophthalmoplegia, Sympathetic,Ocular Ophthalmoplegias, Sympathetic,Ocular-Ophthalmoplegia, Sympathetic,Ocular-Ophthalmoplegias, Sympathetic,Oculosympathetic Syndromes,Ophthalmoplegias, Sympathetic Ocular,Pupil Horner's Syndrome,Sympathetic Ocular Ophthalmoplegia,Sympathetic Ocular Ophthalmoplegias,Sympathetic Ocular-Ophthalmoplegias,Syndrome, Acquired Horner,Syndrome, Bernard,Syndrome, Bernard's,Syndrome, Central Horner,Syndrome, Claude Bernard-Horner,Syndrome, Horner,Syndrome, Horner's,Syndrome, Oculosympathetic,Syndrome, Pupil Horner's,Syndromes, Bernard,Syndromes, Oculosympathetic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

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