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Levels of glutathione peroxidase (GSH-PX), glutathione-S-transferase (GST), gamma-glutamyl transpeptidase (gamma GTP) and glutathione reductase (GR) activities in the B16-F10 metastatic melanoma cell line are higher than those in non-metastatic B-16 murine melanoma cells. An inverse relationship was observed between the level of reduced glutathione (GSH) and metastatic capacity. Interferon (IFN), an antitumour and antimetastic agent, reduced the experimental metastatic capacity of B16-F10 cells while increasing the intracellular GSH content. This was associated with a fall in activity of GSH-metabolizing enzymes. These results suggest a correlation of intracellular GSH and its metabolizing enzymes with malignant transformation.
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
January 1987,
General pharmacology,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
January 1993,
Comparative biochemistry and physiology. B, Comparative biochemistry,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
August 1989,
Cancer letters,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
April 2000,
Toxicology,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
February 2012,
Journal of cutaneous pathology,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
August 1986,
Clinica chimica acta; international journal of clinical chemistry,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
February 2002,
Life sciences,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
October 1980,
Biochemical pharmacology,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
September 1992,
Pharmacological research,
A K Chakraborty, and
M Ueda, and
Y Mishima, and
M Ichihashi
September 1995,
Human cell,
