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Human cytochrome P450IIE1 (CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphisms among lung cancer patients (n = 74) differed from that among controls (n = 73) with statistical significance of p < 0.05. In addition, the distribution among patients with cancers of the digestive system (n = 38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
April 1994,
The American journal of gastroenterology,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
November 2003,
World journal of gastroenterology,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
August 2019,
Cancer medicine,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
February 1998,
Pharmacogenetics,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
November 1989,
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F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
June 2004,
Current drug metabolism,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
December 1987,
Nucleic acids research,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
July 1992,
Biochemical pharmacology,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
September 1996,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
F Uematsu, and
H Kikuchi, and
M Motomiya, and
T Abe, and
C Ishioka, and
R Kanamaru, and
I Sagami, and
M Watanabe
December 1992,
Cancer research,
