Respiratory diseases are in prevalence under the other diseases in industry of leather. The exposition to the chemical irritances like bensen and toluene is very important, because a short exposition gives early symptoms. We found in 54% of examined population pathologic ORL cases in a sense of hypertrophic and atrophic forms rhinitis and pharyngitis. Bacterial flora is pathologic in 20% of examined workers and comparing positive bacteriologic form between nose and pharynges we found infections of mucose of nose more frequent than the throat. The occupational atmosphere and its microclime is very important in pathology of upper respiratory diseases. It is etiological factor in morphological changes of the respiratory mucosas. At the end, we can say that the ordinary monitoring which contains monitoring of working place, and biologic monitoring which means ORL, bacteriological, biochemical and toxicologic examinations must be regulated.