Bacterial motility and chemotaxis. 1992

J P Armitage
Department of Biochemistry, University of Oxford, U.K.

Bacteria swim using the only rotary motor identified in biology. The membrane bound motor uses the gradient of protons set up across the cytoplasmic membrane to drive the rotation of a semi-rigid protein helix, the flagellum. Free-swimming bacteria randomly change direction every few seconds, but if a gradient is encountered the direction-changing frequency can be biased to move the bacterium in a favourable direction. Bacteria respond to changes in chemical concentration, oxygen levels, pH, the intensity or wavelength of light, temperature and in some cases even the Earth's magnetic field and integrate the signals to move towards or maintain the cells in optimum conditions for growth and division. They also adapt to the changes, leaving them free to respond to any subsequent stimuli. Therefore bacteria have something akin to a primitive nervous system, with a sensory system which can respond and adapt to changes and integrate physical and chemical signals. Chemotaxis and motility are involved in infection, both positive (rhizobia) and negative (pathogens) and an understanding of the unique nature of motility and chemotaxis in bacteria may make it possible to control infection. This review will give a brief general overview of current knowledge of bacterial motility and chemotaxis but for more detailed analysis readers are referred to some more specific recent reviews.

UI MeSH Term Description Entries
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D002633 Chemotaxis The movement of cells or organisms toward or away from a substance in response to its concentration gradient. Haptotaxis
D005407 Flagella A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Flagellum
D018407 Bacterial Physiological Phenomena Physiological processes and properties of BACTERIA. Bacterial Physiology,Bacterial Processes,Bacterial Physiological Concepts,Bacterial Physiological Phenomenon,Bacterial Process,Physiology, Bacterial,Bacterial Physiological Concept,Concept, Bacterial Physiological,Concepts, Bacterial Physiological,Phenomena, Bacterial Physiological,Phenomenon, Bacterial Physiological,Process, Bacterial,Processes, Bacterial

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