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Bioassay-guided isolation and identification of antifungal compounds from ginger. 2003
C Ficker, and
M L Smith, and
K Akpagana, and
M Gbeassor, and
J Zhang, and
T Durst, and
R Assabgui, and
J T Arnason
Ottawa-Carleton Institutes of Biology and Chemistry, Carleton University and University of Ottawa, Ottawa ON, Canada.
A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of typical commercial cultivars of ginger. Therefore, ginger extracts standardized on the basis of the identified compounds, could be considered as antifungal agents for practical therapy.
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