Biomaterial Database

The effect of hexamethonium on the carotid chemoreceptor response to nicotine and cyanide. 1961

R BYCK

The literature concerning the effects of ganglionic blocking agents on the chemoreceptors is reviewed. Hexamethonium blocks the respiratory response to intracarotid injections of small doses of nicotine in dogs anaesthetized with chloralose, but it does not block the response to sodium cyanide.

UI	MeSH Term	Description	Entries
D009538	Nicotine	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.	Nicotine Bitartrate,Nicotine Tartrate
D002344	Carotid Body	A small cluster of chemoreceptive and supporting cells located near the bifurcation of the internal carotid artery. The carotid body, which is richly supplied with fenestrated capillaries, senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control.	Glomus Caroticum,Bodies, Carotid,Body, Carotid,Caroticum, Glomus,Carotid Bodies
D002628	Chemoreceptor Cells	Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.	Chemoreceptive Cells,Cell, Chemoreceptive,Cell, Chemoreceptor,Cells, Chemoreceptive,Cells, Chemoreceptor,Chemoreceptive Cell,Chemoreceptor Cell
D003486	Cyanides	Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.	Cyanide,Isocyanide,Isocyanides
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006584	Hexamethonium Compounds	Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.	Compounds, Hexamethonium
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D018738	Hexamethonium	A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.	Depressin,Hexamethonium Bitartrate,Hexamethonium Bromide,Hexamethonium Chloride,Hexamethonium Dibromide,Hexamethonium Dibromide Dihydrate,Hexamethonium Dichloride Dihydrate,Hexamethonium Dihydroxide,Hexamethonium Diiodide,Hexamethonium Dimethylsulfate,Hexamethonium Diperchlorate,Hexamethonium Iodide,Hexamethonium Monotartrate,Hexonium,Bitartrate, Hexamethonium,Bromide, Hexamethonium,Chloride, Hexamethonium,Dibromide Dihydrate, Hexamethonium,Dibromide, Hexamethonium,Dichloride Dihydrate, Hexamethonium,Dihydrate, Hexamethonium Dibromide,Dihydrate, Hexamethonium Dichloride,Dihydroxide, Hexamethonium,Diiodide, Hexamethonium,Dimethylsulfate, Hexamethonium,Diperchlorate, Hexamethonium,Iodide, Hexamethonium,Monotartrate, Hexamethonium