Daily rhythm of aspartate aminopeptidase activity in the retina, pineal gland and occipital cortex of the rat. 1992

M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
Department of Physiology, Medical School, University of the Basque Country, Leioa, Spain.

The levels of specific soluble aspartyl aminopeptidase activity were assayed in retina, occipital cortex, anterior pituitary, posterior pituitary, pineal gland and serum of adult male rats, using Asp-2-naphthylamide as substrate, in a 12:12 h light:dark cycle (7-19 h light). Significant diurnal variations appeared in retina, pineal gland, occipital cortex and serum. In addition, different patterns of diurnal variation of the enzymatic activity were observed in the tissues analyzed. A regular increase of the activity was noticed at the end of the dark period in all the tissues as a common feature, except in serum, in which the enzymatic activity reached a peak in the middle of the light period, decreasing progressively during the dark hours. After the last hours of darkness, the pattern of variation in the activity differed in each tissue. These diurnal variations in aspartyl aminopeptidase activity could reflect the functional status of its putative endogenous substrates, such as angiotensin II, and it may also suggest the existence of differential regulatory mechanisms associated with each location.

UI MeSH Term Description Entries
D008297 Male Males
D009778 Occipital Lobe Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch. Annectant Gyrus,Calcarine Fissure,Calcarine Sulcus,Cuneate Lobule,Cuneus,Cuneus Cortex,Cuneus Gyrus,Gyrus Lingualis,Lingual Gyrus,Lunate Sulcus,Medial Occipitotemporal Gyrus,Occipital Cortex,Occipital Gyrus,Occipital Region,Occipital Sulcus,Sulcus Calcarinus,Calcarine Fissures,Calcarinus, Sulcus,Cortex, Cuneus,Cortex, Occipital,Cortices, Cuneus,Cortices, Occipital,Cuneate Lobules,Cuneus Cortices,Fissure, Calcarine,Fissures, Calcarine,Gyrus Linguali,Gyrus, Annectant,Gyrus, Cuneus,Gyrus, Lingual,Gyrus, Medial Occipitotemporal,Gyrus, Occipital,Linguali, Gyrus,Lingualis, Gyrus,Lobe, Occipital,Lobes, Occipital,Lobule, Cuneate,Lobules, Cuneate,Occipital Cortices,Occipital Lobes,Occipital Regions,Occipitotemporal Gyrus, Medial,Region, Occipital,Regions, Occipital,Sulcus, Calcarine,Sulcus, Lunate,Sulcus, Occipital
D010870 Pineal Gland A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES. Epiphysis Cerebri,Pineal Body,Corpus Pineale,Gland, Pineal,Pineal Bodies,Pineal Glands
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D000626 Aminopeptidases A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11. Aminopeptidase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D043384 Glutamyl Aminopeptidase A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM. Aminopeptidase A,Angiotensinase A,Aspartate Aminopeptidase,Aspartyl Aminopeptidase,Aminopeptidase, Aspartate,Aminopeptidase, Aspartyl,Aminopeptidase, Glutamyl

Related Publications

M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
March 1960, Nature,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 2004, Brain research. Molecular brain research,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
September 2011, Journal of neurochemistry,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1999, Physiological research,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
October 1994, General and comparative endocrinology,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1983, Acta anatomica,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1988, Peptides,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1990, Journal of pineal research,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1988, Peptides,
M Ramírez, and B Sánchez, and G Aréchaga, and P Lardelli, and D Venzon, and S García, and A Ozaita, and J M de Gandarias
January 1982, Investigative ophthalmology & visual science,
Copied contents to your clipboard!