[Hematopoietic growth factors. Biology and clinical applications]. 1992

M Trnĕný, and P Klener
I. interní klinika 1. lékarské fakulty Univerzity Karlovy, Praha.

The authors present an account of haematopoietic growth factors which include the stem cell factor (SCF), factors stimulating granulocytomacrophage colonies (GM-CSF), granulocyte (G-CSF), monocytomacrophage (M-CSF) factors, erythropoietin (EPO) and also interleukin (IL) 1 to 11. Their main action is described as well as the site of action in haematopoiesis. In many of them participation in the pathogenesis of some diseases, incl. malignant ones, is anticipated. The preparation of growth factors in a recombinant-form and knowledge of their effect made it possible to use them in clinical practice. The authors mention possible indications, although in many their administration still has the character of clinical studies.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016298 Hematopoietic Cell Growth Factors These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes. Hematopoietins,Hematopoietic Cell Growth Factor,Hematopoietic Stem Cell Stimulators,Hematopoietic Stem Cell-Activating Factors,Hematopoietic-CGF,Hematopoietic CGF

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