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The Leukocytic cell-adhesion molecule (beta 2 integrin) family of adhesion molecules play a key role in the intercellular adhesive interactions necessary for normal immune cell function. In this study, we report an antibody that recognizes an epitope on the Leukocytic cell-adhesion molecule common beta-chain (CD18) and promotes both lymphocyte function-associated Ag-1- and CR3-dependent adhesion events. The antibody recognizes a temperature-sensitive epitope that is not dependent on the presence of divalent cations. It is proposed that antibody binding promotes a conformational change in both lymphocyte function-associated Ag-1 and CR3, which may mimic a natural activation mechanism, resulting in increased cellular adhesion.
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
May 1990,
European journal of immunology,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
July 1985,
European journal of immunology,
M K Robinson, and
D Andrew, and
H Rosen, and
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E C Butcher
April 1994,
Leukemia & lymphoma,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
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E C Butcher
May 1993,
Journal of immunology (Baltimore, Md. : 1950),
M K Robinson, and
D Andrew, and
H Rosen, and
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S Ortlepp, and
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E C Butcher
May 1996,
Blood,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
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E C Butcher
January 1995,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
August 1994,
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
April 1992,
Journal of immunology (Baltimore, Md. : 1950),
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
January 1990,
Folia biologica,
M K Robinson, and
D Andrew, and
H Rosen, and
D Brown, and
S Ortlepp, and
P Stephens, and
E C Butcher
March 1990,
The Journal of clinical investigation,
