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Thirty compounds of various chemical classes were investigated for mutagenicity in a collaborative study (3 laboratories) using Salmonella typhimurium TA102. With 5 compounds, namely hydrazine sulfate, phenylhydrazine, hydralazine, glutardialdehyde and glyoxal, mutagenicity was detected by all laboratories. Formaldehyde was assessed as weakly mutagenic in only 1 of 3 laboratories. The remaining 24 agents were uniformly described as non-genotoxic in TA102. In spite of the overall good qualitative agreement in the mutagenicity results between the 3 laboratories some quantitative discrepancies occurred in the dose response of the mutagenic compounds. Varying inter- and intra-laboratory differences in the spontaneous rate of revertants were obtained. The usefulness of the tester strain TA102 in routine mutagenicity testing is discussed.
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
January 1985,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
May 1994,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
January 1988,
Environmental and molecular mutagenesis,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
January 2004,
Anticancer research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
November 1988,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
September 1986,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
November 1991,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
December 1996,
Mutation research,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
May 1990,
Mutagenesis,
R Jung, and
G Engelhart, and
B Herbolt, and
R Jäckh, and
W Müller
August 1994,
Carcinogenesis,
