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Unsubstituted anthraquinone, 4 substituted anthraquinones (emodin, danthron, physcion, a new compound M-108-C) and 3 dimers (skyrin, rugulosin, rugulin) were tested using the Ames/Salmonella assay (strains TA98, TA100, TA1537 and TA102). Danthron and emodin were found to be mutagenic for TA1537 with or without metabolic activation, physcion only with metabolic activation. A significant difference was found between the mutagenic activities of emodin (16.2 His+/nmole) and danthron (6.5 His+/nmole) as well as a high specific mutagenic activity for physcion (11.6 His+/nmole). These results on structure-mutagenic activity relationships suggest that the 6-methyl group plays an important role in the mutagenic activity after metabolic activation. Furthermore, and contrary to emodin, physcion exhibited a weak mutagenic activity for TA102, probably due to the formation of a different metabolite. Such information is necessary to evaluate the potential carcinogenic hazard of these compounds.
S Krivobok, and
F Seigle-Murandi, and
R Steiman, and
D R Marzin, and
V Betina
June 1982,
Applied and environmental microbiology,
S Krivobok, and
F Seigle-Murandi, and
R Steiman, and
D R Marzin, and
V Betina
November 2000,
Mutation research,
S Krivobok, and
F Seigle-Murandi, and
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V Betina
August 1979,
Mutation research,
S Krivobok, and
F Seigle-Murandi, and
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V Betina
January 1985,
Environmental mutagenesis,
S Krivobok, and
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V Betina
February 1980,
Veterinary and human toxicology,
S Krivobok, and
F Seigle-Murandi, and
R Steiman, and
D R Marzin, and
V Betina
February 1979,
Mutation research,
S Krivobok, and
F Seigle-Murandi, and
R Steiman, and
D R Marzin, and
V Betina
January 1980,
Mutation research,
S Krivobok, and
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V Betina
May 2019,
Mutation research. Genetic toxicology and environmental mutagenesis,
S Krivobok, and
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R Steiman, and
D R Marzin, and
V Betina
January 1982,
Applied and environmental microbiology,
S Krivobok, and
F Seigle-Murandi, and
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D R Marzin, and
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May 1990,
Journal of dental research,
