Observations on the pyrogenic response and its application to the bioassay of endotoxin.
1961
W R KEENE, and
H R SILBERMAN, and
M LANDY
UI
MeSH Term
Description
Entries
D004731
Endotoxins
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Endotoxin
D005334
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Pyrexia,Fevers,Pyrexias
D006801
Humans
Members of the species Homo sapiens.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001681
Biological Assay
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.