-transparent.png){kind=logo}
1. The relaxant actions of acetylcholine, substance P and calcitonin gene-related peptide, and the levels of neuropeptide Y and calcitonin gene-related peptide were assessed in the rabbit central ear artery 1, 4 and 6 weeks after a single dose of 45 Gy X-irradiation, a dose similar to that used clinically in intraoperative radiotherapy. 2. Relaxant responses induced by acetylcholine and substance P (both endothelium-dependent) and calcitonin gene-related peptide (endothelium-independent) were reduced, and endogenous neuropeptide Y and calcitonin gene-related peptide levels were unaffected after X-irradiation. 3. The mechanism(s) by which a single dose of 45 Gy X-irradiation may selectively damage relaxant, but not direct, contractile responses of the smooth muscle (as we have shown previously) of the rabbit central ear artery are discussed.
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
December 1999,
Anesthesia and analgesia,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
April 1968,
Investigative ophthalmology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
January 2006,
Vascular pharmacology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
July 1972,
The Journal of physiology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
September 1993,
General pharmacology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
April 1988,
The Journal of pharmacology and experimental therapeutics,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
November 1974,
The Journal of experimental zoology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
June 1973,
The Australian journal of experimental biology and medical science,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
February 1998,
British journal of pharmacology,
K I Maynard, and
A L Stewart-Lee, and
P Milner, and
G Burnstock
February 1967,
Radiation research,
