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The effect of substance P (SP) on the activities of oviductal isthmic smooth muscle in rabbits was studied. Rabbits were divided into estrous, diestrous and ovariectomized groups. The results were as follows: (1) SP suppressed the activity of the oviductal isthmic smooth muscle in diestrous rabbit (P less than 0.05). (2) SP did not suppress the activities of the oviductal isthmic smooth muscles in estrous and ovariectomized rabbits (P greater than 0.05).
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