-transparent.png){kind=logo}
The clinical significance and detection methods for circulating activated platelets are reviewed. It has been recently demonstrated that three kinds of platelet granules, dense granule, alpha-granule and lysosome, have specific membrane proteins; granulophysin, GMP-140 (PADGEM) and CD63 antigen, respectively, and that these specific granule-membrane proteins become exposed on the surface of the activated platelets. It is believed that detection of circulating activated platelets, using monoclonal antibodies specific to these granule-membrane, may be reliable and diagnostic value in thrombotic and prethrombotic diseases. Preliminary clinical studies using 2T60, a newly developed anti-GMP-140 monoclonal antibody, was presented.
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
January 1993,
Journal of clinical laboratory analysis,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
January 1993,
Haemostasis,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
February 1991,
Journal of cellular biochemistry,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
January 1991,
Trends in cardiovascular medicine,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
January 1991,
Current studies in hematology and blood transfusion,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
February 1990,
Blood,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
November 2005,
Zhonghua yi xue za zhi,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
February 1990,
Nature,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
January 1990,
Nouvelle revue francaise d'hematologie,
K Tanoue, and
N Akamatsu, and
H Suzuki, and
Y Katagiri, and
H Yamazaki, and
T Fujimoto, and
S Fukuda, and
Y Onozawa
March 1992,
Rinsho byori. The Japanese journal of clinical pathology,
