-transparent.png){kind=logo}
The effects of decreasing blood viscosity by normovolemic hemodilution with dextran-40 or normal saline (NS) on myocardial lipid peroxides, superoxide dismutase, infarct size and left ventricular function during acute myocardial ischemia/reperfusion were studied in rabbits. It was found that normovolemic hemodilution with dextran-40 could decrease the content of ischemic myocardial malondialdehyde and preserve ischemic myocardial superoxide dismutase activity after 1 h of coronary occlusion followed by 1 h of reperfusion. However, after administration of NS only a tendency in this aspect exhibited without statistical significance. Besides, hemodilution with dextran-40 reduced infarct size and improved left ventricular systolic function after 1 h of ischemia followed by 23 h of reperfusion. These results suggest that normovolemic hemodilution with dextran-40 may have anti-injury effect on acute myocardial ischemia/reperfusion to a certain degree.
H D Ruan, and
C R Dong, and
H Ling
August 1995,
Cardiovascular surgery (London, England),
H D Ruan, and
C R Dong, and
H Ling
February 1991,
Journal of cardiothoracic and vascular anesthesia,
H D Ruan, and
C R Dong, and
H Ling
January 1997,
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University,
H D Ruan, and
C R Dong, and
H Ling
January 2016,
American journal of therapeutics,
H D Ruan, and
C R Dong, and
H Ling
May 1975,
The Journal of surgical research,
H D Ruan, and
C R Dong, and
H Ling
January 1997,
Clinical hemorheology and microcirculation,
H D Ruan, and
C R Dong, and
H Ling
February 2001,
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University,
H D Ruan, and
C R Dong, and
H Ling
March 1983,
Canadian journal of surgery. Journal canadien de chirurgie,
H D Ruan, and
C R Dong, and
H Ling
January 1990,
Basic research in cardiology,
H D Ruan, and
C R Dong, and
H Ling
July 2009,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
