BIOMAT Database Logo BIOMAT Database Logo

dup(12)(q13----qter) in two t(14;18)-negative follicular B-non-Hodgkin's lymphomas. 1992

I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Center for Human Genetics, University of Leuven, Belgium.

Two t(14;18)-negative follicular B-non-Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13----qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13----qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B-chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B-non-Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved-cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center-cell lymphomas.

UI MeSH Term Description Entries
D008224 Lymphoma, Follicular Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. Brill-Symmers Disease,Follicular Lymphoma,Lymphoma, Giant Follicular,Lymphoma, Nodular,Follicular Large-Cell Lymphoma,Follicular Lymphoma, Giant,Follicular Lymphoma, Grade 1,Follicular Lymphoma, Grade 2,Follicular Lymphoma, Grade 3,Follicular Mixed-Cell Lymphoma,Giant Follicular Lymphoma,Histiocytic Lymphoma, Nodular,Large Lymphoid Lymphoma, Nodular,Large-Cell Lymphoma, Follicular,Lymphocytic Lymphoma, Nodular, Poorly Differentiated,Lymphocytic Lymphoma, Nodular, Poorly-Differentiated,Lymphoma, Follicular Large-Cell,Lymphoma, Follicular, Grade 1,Lymphoma, Follicular, Grade 2,Lymphoma, Follicular, Grade 3,Lymphoma, Follicular, Mixed Cell,Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic,Lymphoma, Follicular, Mixed Small and Large Lymphoid,Lymphoma, Follicular, Small and Large Cleaved Cell,Lymphoma, Follicular, Small and Large Cleaved-Cell,Lymphoma, Histiocytic, Nodular,Lymphoma, Large Cell, Follicular,Lymphoma, Large Lymphoid, Nodular,Lymphoma, Large-Cell, Follicular,Lymphoma, Lymphocytic, Nodular, Poorly Differentiated,Lymphoma, Lymphocytic, Nodular, Poorly-Differentiated,Lymphoma, Mixed-Cell, Follicular,Lymphoma, Nodular, Large Follicular Center Cell,Lymphoma, Nodular, Large Follicular Center-Cell,Lymphoma, Nodular, Mixed Lymphocytic Histiocytic,Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic,Lymphoma, Nodular, Mixed Small and Large Cell,Lymphoma, Small Cleaved Cell, Follicular,Lymphoma, Small Cleaved-Cell, Follicular,Lymphoma, Small Follicular Center-Cell,Lymphoma, Small Lymphoid, Follicular,Mixed-Cell Lymphoma, Follicular,Nodular Large Follicular Center-Cell Lymphoma,Small Cleaved-Cell Lymphoma, Follicular,Small Follicular Center-Cell Lymphoma,Brill Symmers Disease,Disease, Brill-Symmers,Follicular Large Cell Lymphoma,Follicular Large-Cell Lymphomas,Follicular Lymphomas,Follicular Lymphomas, Giant,Follicular Mixed Cell Lymphoma,Follicular Mixed-Cell Lymphomas,Giant Follicular Lymphomas,Histiocytic Lymphomas, Nodular,Large Cell Lymphoma, Follicular,Large-Cell Lymphomas, Follicular,Lymphoma, Follicular Large Cell,Lymphoma, Follicular Mixed-Cell,Lymphoma, Nodular Histiocytic,Lymphoma, Small Follicular Center Cell,Lymphomas, Follicular,Lymphomas, Follicular Large-Cell,Lymphomas, Follicular Mixed-Cell,Lymphomas, Giant Follicular,Lymphomas, Nodular,Lymphomas, Nodular Histiocytic,Mixed Cell Lymphoma, Follicular,Mixed-Cell Lymphomas, Follicular,Nodular Histiocytic Lymphoma,Nodular Histiocytic Lymphomas,Nodular Large Follicular Center Cell Lymphoma,Nodular Lymphoma,Nodular Lymphomas,Small Cleaved Cell Lymphoma, Follicular,Small Follicular Center Cell Lymphoma
D009693 Nucleic Acid Hybridization Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503) Genomic Hybridization,Acid Hybridization, Nucleic,Acid Hybridizations, Nucleic,Genomic Hybridizations,Hybridization, Genomic,Hybridization, Nucleic Acid,Hybridizations, Genomic,Hybridizations, Nucleic Acid,Nucleic Acid Hybridizations
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002881 Chromosomes, Human, Pair 12 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 12
D002883 Chromosomes, Human, Pair 14 A specific pair of GROUP D CHROMOSOMES of the human chromosome classification. Chromosome 14
D002887 Chromosomes, Human, Pair 18 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 18
D005260 Female Females
D005453 Fluorescence The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.
September 2023, Blood advances,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Alternative end-joining in follicular lymphomas' t(14;18) translocation.
January 2002, Leukemia,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Proliferative fraction and DNA content are lower in B-cell non-Hodgkin's lymphomas with the t(14;18).
October 1995, Leukemia & lymphoma,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.
March 2009, British journal of haematology,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Follicular dendritic cells in non-Hodgkin's lymphomas.
September 1994, Leukemia & lymphoma,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin's lymphomas.
April 1994, Leukemia research,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Correlation between cytogenetic and molecular analysis of t(14;18) in follicular lymphomas.
March 1992, Cancer genetics and cytogenetics,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Bcl-3/IgH translocation (14;19)(q32;q13) in non-Hodgkin's lymphomas.
April 2002, Leukemia & lymphoma,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Memory T cell subsets in B cell non-Hodgkin's lymphomas.
January 1996, Leukemia & lymphoma,
I Wlodarska, and C Mecucci, and E Vandenberghe, and C De Wolf-Peeters, and J Thomas, and C Hilliker, and E Schoenmakers, and M Stul, and P Marynen, and J J Cassiman
Quantitation of follicular non-Hodgkin's lymphoma cells carrying t(14;18) by competitive polymerase chain reaction.
June 1993, British journal of haematology,
Copied contents to your clipboard!