Biomaterial Database

Clastogenicity of 2-chlorobenzylidene malonitrile (CS) in V79 Chinese hamster cells. 1992

M Bauchinger, and E Schmid

Institut für Strahlenbiologie, GSF-Forschungszentrum für Umwelt und Gesundheit mbH, Neuherberg, Germany.

The clastogenicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated at various exposure conditions. CS efficiently induced chromatid-type aberrations in a dose-dependent manner provided the cells could run through at least one or two S-phases during a 20-h exposure over a 3-h exposure followed by a 20-h recovery period (cell cycle time 8-10 h). The induction of SCEs indicates an S-dependent mechanism. The hydrolysis products o-chlorobenzaldehyde and malonitrile were inactive in these experiments.

UI	MeSH Term	Description	Entries
D009153	Mutagens	Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.	Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009763	o-Chlorobenzylidenemalonitrile	A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.	o-Chlorobenzylidene Malonitrile,ortho-Chlorobenzylidenemalonitrile,2-Chlorobenzylidene Malonitrile,2-Chlorobenzylidenemalonitrile,CS Tear Gas,o-Chlorobenzylidene malonotrile,ortho-Chlorobenzylidene Malonitrile,2 Chlorobenzylidene Malonitrile,2 Chlorobenzylidenemalonitrile,Malonitrile, 2-Chlorobenzylidene,Malonitrile, o-Chlorobenzylidene,Malonitrile, ortho-Chlorobenzylidene,Tear Gas, CS,malonotrile, o-Chlorobenzylidene,o Chlorobenzylidene Malonitrile,o Chlorobenzylidene malonotrile,o Chlorobenzylidenemalonitrile,ortho Chlorobenzylidene Malonitrile,ortho Chlorobenzylidenemalonitrile
D002455	Cell Division	The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.	M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002460	Cell Line	Established cell cultures that have the potential to propagate indefinitely.	Cell Lines,Line, Cell,Lines, Cell
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

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