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The persistence of chromosomal lesions induced in vivo by mitomycin C (MMC) was evaluated by cytogenetic analysis of mouse bone marrow cells. Chromosome aberration (CA) and micronucleus (MN) frequencies were estimated at different times after treatment, up to 42 days. The frequency of CA per cell decreased in the first 3 days after treatment, but a secondary peak appeared on the 4th day, followed by a stabilization around 0.03 CA per cell (significantly different from the control value), which persisted up to 17 days. At the next time intervals tested (28 and 42 days), the CA frequency returned to the control level. In disagreement with these data obtained directly on metaphases, the MN frequency, as evaluated in polychromatic erythrocytes, decreased quickly after treatment, reaching the control value on the 5th day. We attempted to enhance the sensitivity of the MN test by using CREST antibodies and indirect immunofluorescence. However, higher proportions of CREST- MN in treated than in control animals were observed only at short time intervals, confirming the results obtained with the conventional MN assay.
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
January 1986,
Radiobiologiia,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
January 1981,
Mutation research,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
July 2005,
Environmental toxicology and pharmacology,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
January 1992,
Environmental and molecular mutagenesis,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
December 2007,
Acta biologica Hungarica,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
September 1999,
International journal of radiation biology,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
December 1999,
Biomedical and environmental sciences : BES,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
March 1985,
Mutation research,
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
October 1994,
Lancet (London, England),
A Russo, and
A Stocco, and
L Renzi, and
N Bianco, and
F Majone
January 1996,
Cytobios,
