Biomaterial Database

Thyroid hormone regulation of human pituitary alpha subunit gene expression. 1992

M C Sheppard, and J A Franklyn, and N J Yarwood, and J A Gurr

Department of Medicine, University of Birmingham, United Kingdom.

The thyroid hormone T3 exerts an inhibitory effect upon pre-translational expression of the alpha subunit gene in the anterior pituitary. In the intact animal oestrogen alone is without effect upon alpha gene expression but oestrogen modulates the influence of T3 deficiency upon the alpha gene. T3 effects upon alpha transcription are mediated via sequences within 98 bp of the transcriptional start site of the gene and similar 5' flanking sequences of the alpha gene mediate both T3 regulation and oestrogen modulation of T3 inhibition. This oestrogen effect may be mediated directly via interaction of the oestrogen receptor with the alpha gene thyroid hormone response element to which the oestrogen receptor is able to bind.

UI	MeSH Term	Description	Entries
D004967	Estrogens	Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.	Estrogen,Estrogen Effect,Estrogen Effects,Estrogen Receptor Agonists,Estrogenic Agents,Estrogenic Compounds,Estrogenic Effect,Estrogenic Effects,Agents, Estrogenic,Agonists, Estrogen Receptor,Compounds, Estrogenic,Effects, Estrogen,Effects, Estrogenic,Receptor Agonists, Estrogen
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013963	Thyroid Hormones	Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.	Thyroid Hormone,Hormone, Thyroid,Hormones, Thyroid
D013972	Thyrotropin	A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.	Thyroid-Stimulating Hormone,TSH (Thyroid Stimulating Hormone),Thyreotropin,Thyrotrophin,Hormone, Thyroid-Stimulating,Thyroid Stimulating Hormone
D015292	Glycoprotein Hormones, alpha Subunit	The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.	FSH, alpha Subunit,Follicle-Stimulating Hormone, alpha Subunit,LH, alpha Subunit,Luteinizing Hormone, alpha Subunit,Pituitary Glycoprotein Hormone, alpha Subunit,TSH, alpha Subunit,Thyroid-Stimulating Hormone, alpha Subunit,Thyrotropin alpha Subunit,ASGPH,Chorionic Gonadotropin, alpha,Chorionic Gonadotropin, alpha Subunit,Common alpha Subunit Glycoprotein Hormones,FSH-alpha,Follicle Stimulating Hormone, alpha Subunit,Glycoprotein Hormones, alpha Chain,Glycoprotein Hormones, alpha Polypeptide,Lutotropin-alpha,TSH-alpha,FSH alpha,Lutotropin alpha,TSH alpha,Thyroid Stimulating Hormone, alpha Subunit