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We investigated the possibility of nitric oxide (NO), a powerful vasodilator agent, being synthesized by perivascular nerve fibres. Immunoreactivity and catalytic activity of the NO synthesizing enzyme, NO synthase (NOS), were demonstrated in perivascular nerve fibres of blood vessels receiving autonomic vasodilator innervation, but not of those innervated exclusively by vasoconstrictor nerve fibres. Double-labelling techniques allowed identification of NOS-containing nerve fibres as belonging to the vasoactive intestinal peptide (VIP)/acetylcholine-containing class whereas noradrenergic and substance P-containing perivascular fibres were devoid of NOS. We suggest that, in addition to its endothelial source, NO is a neuronal co-mediator of VIP/cholinergic vasodilation.
W Kummer, and
A Fischer, and
P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
April 2000,
Journal of the autonomic nervous system,
W Kummer, and
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P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
March 1994,
Neuroreport,
W Kummer, and
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P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
January 1994,
Journal of the autonomic nervous system,
W Kummer, and
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P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
April 1996,
Cell and tissue research,
W Kummer, and
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P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
March 1995,
Journal of the autonomic nervous system,
W Kummer, and
A Fischer, and
P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
October 1994,
Microscopy research and technique,
W Kummer, and
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P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
August 1998,
Neuroscience letters,
W Kummer, and
A Fischer, and
P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
May 2000,
BJU international,
W Kummer, and
A Fischer, and
P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
December 1992,
Circulation research,
W Kummer, and
A Fischer, and
P Mundel, and
B Mayer, and
B Hoba, and
B Philippin, and
U Preissler
July 1998,
Journal of the autonomic nervous system,
