Biomaterial Database

[Kynurenine and its metabolites in nervous system diseases]. 1992

L Vécsei, and F Schwab

Pécsi Orvostudományi Egyetem, Neurológiai Klinika.

Kynurenine is a metabolite of the tryptophan-nicotine-amide-adenine-dinucleotide pathway. Recent preclinical and clinical data suggest that kynurenine and its metabolites (kynurenic acid, quinolinic acid) may play important role in the pathogenesis of neurological and other disorders (Huntington's disease, epilepsy, hypoxia, ulcus, hepatic and infectious diseases). Experimental data and theoretical considerations suggest that modification of kynurenine metabolism and influence of the concentrations of kynurenine metabolites may be useful therapeutic strategies in treatment of several disorders. This review is a summary of the pathobiochemical mechanisms and possible therapeutic strategies.

UI	MeSH Term	Description	Entries
D007736	Kynurenic Acid	A broad-spectrum excitatory amino acid antagonist used as a research tool.	Kynurenate,Acid, Kynurenic
D007737	Kynurenine	A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
D009422	Nervous System Diseases	Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	Neurologic Disorders,Nervous System Disorders,Neurological Disorders,Disease, Nervous System,Diseases, Nervous System,Disorder, Nervous System,Disorder, Neurologic,Disorder, Neurological,Disorders, Nervous System,Disorders, Neurologic,Disorders, Neurological,Nervous System Disease,Nervous System Disorder,Neurologic Disorder,Neurological Disorder
D011805	Quinolinic Acids	Dicarboxylic acids with a PYRIDINE backbone. Quinolinic Acids are downstream products of the KYNURENINE pathway which metabolize amino acid TRYPTOPHAN.	Acids, Quinolinic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017378	Quinolinic Acid	A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.	Quinolinate,Quinolinic Acid, Copper(2+) Salt,Quinolinic Acid, Disodium Salt,Quinolinic Acid, Strontium Salt