Increased level of dihydrofolic reductase in leucocytes of patients treated with amethopterin. 1962

J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008727 Methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Amethopterin,Methotrexate Hydrate,Methotrexate Sodium,Methotrexate, (D)-Isomer,Methotrexate, (DL)-Isomer,Methotrexate, Dicesium Salt,Methotrexate, Disodium Salt,Methotrexate, Sodium Salt,Mexate,Dicesium Salt Methotrexate,Hydrate, Methotrexate,Sodium, Methotrexate
D010088 Oxidoreductases The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9) Dehydrogenases,Oxidases,Oxidoreductase,Reductases,Dehydrogenase,Oxidase,Reductase
D005493 Folic Acid Antagonists Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) Antifolate,Antifolates,Dihydrofolate Reductase Inhibitor,Folic Acid Antagonist,Dihydrofolate Reductase Inhibitors,Folic Acid Metabolism Inhibitors,Acid Antagonist, Folic,Acid Antagonists, Folic,Antagonist, Folic Acid,Antagonists, Folic Acid,Inhibitor, Dihydrofolate Reductase,Inhibitors, Dihydrofolate Reductase,Reductase Inhibitor, Dihydrofolate,Reductase Inhibitors, Dihydrofolate

Related Publications

J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
February 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
January 1967, Enzymologia biologica et clinica,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
November 1967, Archives of dermatology,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
June 1958, Nature,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
June 1962, Cancer research,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
January 1967, Enzymologia biologica et clinica,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
March 1966, The Journal of biological chemistry,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
August 1966, Proceedings of the National Academy of Sciences of the United States of America,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
January 1970, Acta dermato-venereologica,
J R BERTINO, and D R DONOHUE, and B W GABRIO, and R SILBER, and A ALENTY, and M MEYER, and F M HUENNEKENS
October 1963, The Journal of biological chemistry,
Copied contents to your clipboard!