-transparent.png){kind=logo}
Teicoplanin-impregnated plaster of Paris beads were made and in vitro release properties were studied. Teicoplanin was released in an initial massive dose, with a rapid decline during the first three days, followed by a slowly declining prolonged release up to 30 days. The release tested by diffusion in gelose and high-performance liquid chromatography was found to be 21.4% and 28.2%, respectively, of the amount theoretically present in the beads. Plaster of Paris is a resorbable, nontoxic biomaterial that has already been used to fill dead spaces in bone and deliver antibiotics in the treatment of chronic osteomyelitis. The addition of teicoplanin, a new antistaphylococcal agent with low known bacterial resistance, is a promising alternative. Follow-up tests in vivo, simulating local conditions of the osteomyelitic bone, are necessary to prove efficacy.
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
January 2014,
Veterinary and comparative orthopaedics and traumatology : V.C.O.T,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
August 2010,
Veterinary surgery : VS,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
June 1990,
Pathologie-biologie,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
January 1993,
Revue de chirurgie orthopedique et reparatrice de l'appareil moteur,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
January 2003,
Veterinary surgery : VS,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
April 1991,
Orthopaedic review,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
January 1984,
The Journal of the Kentucky Medical Association,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
March 1994,
The Journal of trauma,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
November 1991,
Surgical technology international,
V Dacquet, and
A Varlet, and
R N Tandogan, and
M M Tahon, and
L Fournier, and
F Jehl, and
H Monteil, and
G Bascoulergue
February 1997,
Antimicrobial agents and chemotherapy,
