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The pharmacokinetics of atracurium, which is degraded by Hofmann decomposition and ester hydrolysis, is not altered by impaired liver function. Atracurium should, therefore, be ideal for patients with heptic failure, and is now widely used in clinical practice. However, some studies reported considerable hepatotoxicity after atracurium, especially from its breakdown products--for example, leakage of lactate dehydrogenase (LDH) from isolated rat hepatocytes. Therefore, we have studied, in an isolated perfused rat liver model, biochemical and morphological changes after administration of either atracurium or its main metabolite, laudanosine. Despite using extremely high concentrations of these substances, we could not detect, biochemically (release of LDH or aspartate amino-transferase (AST)) or histologically, any signs of liver cell damage.
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
June 1980,
Experimental and molecular pathology,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
December 1997,
Toxicology,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
January 1997,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
February 1985,
Acta pharmacologica et toxicologica,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
January 1989,
Journal of toxicology and environmental health,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
May 1978,
International archives of occupational and environmental health,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
March 1993,
Anesthesia and analgesia,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
December 1989,
British journal of anaesthesia,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
July 2002,
European journal of anaesthesiology,
H Reckendorfer, and
H Burgmann, and
M Sperlich, and
G L Tüchy, and
W Feigl, and
P G Spieckermann, and
M Weindlmayr-Göttel, and
S Schwarz
March 1991,
Anesthesiology,
