-transparent.png){kind=logo}
Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A protein meal significantly decreased Cmax [532 (228 s.d.) vs 802 (452 s.d.) ng ml-1, P = 0.004] and increased mean residence time (138 (26 s.d.) vs 114 (26 s.d.) min, corrected for lag times, P = 0.001). However, AUC, tmax, terminal half-life and renal clearance were not significantly altered (P greater than 0.05). The power to detect a 20% change in AUC was 98% at the 5% significance level. In contrast to fat-containing foods, protein-based meals may not alter the extent of zidovudine absorption.
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
June 2012,
Chinese medical journal,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
January 1990,
Journal of acquired immune deficiency syndromes,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
January 1995,
Blood purification,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
January 1990,
Journal of acquired immune deficiency syndromes,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
March 1993,
The American journal of psychiatry,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
January 1995,
Infection,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
February 1996,
Epilepsy research,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
March 2001,
The Journal of pharmacy and pharmacology,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
May 2007,
European journal of clinical pharmacology,
J Sahai, and
K Gallicano, and
G Garber, and
I McGilveray, and
N Hawley-Foss, and
N Turgeon, and
D W Cameron
May 1990,
American family physician,
